OBJECTIVE: To estimate the cost of scaling up childhood immunization services required to reach the WHO-UNICEF Global Immunization Vision and Strategy (GIVS) goal of reducing mortality due to vaccine-preventable diseases by two-thirds by 2015.METHODS: A model was developed to estimate the total cost of reaching GIVS goals by 2015 in 117 low- and lo
A Rare Case Report of Mandible Osteosarcoma in an 8-Year-Old Child
Introduction: Osteosarcoma of jaw bones is Front Loader Gasket Clamp the most common primary malignant bone tumor arising from mesenchymal cells capable of producing steoid; this disorder predominantly occurs in the long bones and rarely involves the maxillofacial region.Normally, this disease presents in the third and fourth decades of life, is sl
New open-source software for subcellular segmentation and analysis of spatiotemporal fluorescence signals using deep learning
Summary: Cellular imaging instrumentation advancements as well as readily available optogenetic and fluorescence sensors have yielded a profound need for fast, accurate, and standardized analysis.Deep-learning architectures Bed Pillow have revolutionized the field of biomedical image analysis and have achieved state-of-the-art accuracy.Despite thes
Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition
Abstract Background Inhibition of kinases involved in the DNA damage response sensitizes cells to genotoxic agents by abrogating checkpoint-induced cell cycle arrest.CHK1 and WEE1 act in a pathway upstream of CDK1 to inhibit cell cycle progression in response to damaged DNA.Therapeutic targeting of either CHK1 or WEE1, in combination with chemother
Theory of short-term and long-term resistance of structures based on the principle of plastic fracture
The authors analyze the theory used in many countries, containing two independent directions: 1) the theory of stability of rod systems, including flat frames; 2) the theory of calculation of structural elements from various materials.The main Bed Pillow feature of these theories is the application of the principle of plastic fracture.The assumptio